Follow us on Twitter @ESCardioNews The hashtag for ESC Congress 2022 is #ESCCcongress. This press release accompanies both a presentation and an ESC press conference at the ESC 2022 Congress. It does not necessarily reflect the opinion of the European Society of Cardiology. Acknowledgments: The lead author and presenter of the trial results was Dr. Niklas Dyrby Johansen, Center for Translational Cardiology and Practical Randomized Trials, University of Copenhagen, Denmark. Funding: The study was funded by Sanofi who provided the high-dose vaccines for the study and a financial contribution for the remaining costs. Disclosures: JN was previously employed by Sanofi and may own stock and/or stock options in the company. SS, CS, and MML are full-time employees of Sanofi and may own stock and/or stock options in the company. CSL is chief medical officer at Danske Lægers Vaccinations Service, part of the European LifeCare Group, and has received speaker fees and served on advisory boards for GSK, MSD, Pfizer, Takeda and Valneva. BLC has received consulting fees from Amgen, Cardurion, Corvia, Myokardia, and Novartis. SDS has received research grants from Actelion, Alnylam, Amgen, AstraZeneca, Bellerophon, Bayer, BMS, Celladon, Cytokinetics, Eidos, Gilead, GSK, Ionis, Lilly, Mesoblast, MyoKardia, NIH/NHLBI, Neurotronik, Novartis, Revocardia, Sanofi, Theracos, US2.AI and consult for Abbott, Action, Akros, Alnylam, Amgen, Arena, AstraZeneca, Bayer, Boehringer Ingelheim, BMS, Cardior, Cardurion, Corvia, Cytokinetics, Daiichi-Sankyo, GSK, Lilly, Merck, Myokardia , Novartis, Roche, Theracos, Quantum Genomics, Cardurion, Janssen, Cardiac Dimensions, Tenaya, Sanofi, Dinaqor, Tremeau, CellProThera, Moderna, American Regent, Sarepta, Lexicon, Anacardio, Akros and Puretech Health. LK has received speaker fees from Novo Nordisk, Novartis, AstraZeneca, Boehringer Ingelheim, and Bayer. TB-S has served as a steering committee member of the Amgen-sponsored GALACTIC-HF trial and the Boston Scientific-sponsored LUX-Dx TRENDS trial, served on advisory boards for Sanofi and Amgen, received speaker honoraria from Novartis and Sanofi Pasteur and received research grants from GE Healthcare and Sanofi Pasteur. All other authors declare no competing interests. References and notes 1DANFLU-1 will be discussed during: 2Kwong JC, Schwartz KL, Campitelli MA, et al. Acute myocardial infarction after laboratory-confirmed influenza infection. N Engl J Med. 2018? 378:345–353. 3Kytömaa S, Hegde S, Claggett B, et al. Association of influenza-like illness activity with hospitalization for heart failure: the Atherosclerosis Risk in Communities Study. JAMA Cardiol. 2019? 4:363–369. 4Chow EJ, Rolfes MA, O’Halloran A, et al. Influenza-related acute cardiovascular events in hospitalized adults. Ann Intern Med. 2020? 173:605-613. 5Modin D, Jørgensen ME, Gislason G, et al. Influenza vaccine in heart failure. Traffic. 2019? 139:575–586. 6Fröbert O, Götberg M, Erlinge D, et al. Influenza vaccination after myocardial infarction: A randomized, double-blind, placebo-controlled, multicenter trial. Traffic. 2021? 144:1476-1484. 7DiazGranados CA, Dunning AJ, Kimmel M, et al. Efficacy of high-dose versus standard-dose influenza vaccine in older adults. N Engl J Med. 2014? 371:635-645 8DiazGranados CA, Robertson CA, Talbot HK, et al. Prevention of serious events in adults aged 65 years and older: Comparison between high-dose and standard-dose inactivated influenza vaccines. Vaccine. 2015? 33:4988–4993. 9Lee JKH, Lam GKL, Shin T, et al. Effectiveness and efficacy of high-dose influenza vaccine in older adults by circulating strain and antigenic challenge: An updated systematic review and meta-analysis. Vaccine. 2021;39:A24–A35. About the European Society of Cardiology The ESC brings together healthcare professionals from more than 150 countries who work to advance cardiovascular medicine and help people live longer and healthier lives. About ESC Congress 2022 It’s the world’s largest gathering of cardiovascular professionals, disseminating cutting-edge science both on-site and online – August 26-29. Explore the science program. More information is available from the ESC Press Office at [email protected]
